Synthetic and modified isoflavonoids. X. Synthesis of 2-ethyl and 2-propyl homologues of pseudobaptigenin

Homologues of pseudobaptigenin containing ethyl and propyl groups in position 2 have been synthesized. The structures of the new compounds have been comfirmed by PMR.     

Synthesis and isomerization of 2,5- and 2,6-substituted -hexadienes and heptadienes [1]

The reaction of 2,2,3,3,4,4-hexafluoro-1,5-diphenyl-pentane-1,5-dione, 4,4,5,5-tetrafluorooctane-3,6-dione and 4,4,5,5,6,6,-hexafluorononane-3,7-dione with excess triphenyl-phosphine and dibromodifluoromethane in triglyme at 10 °C gave modest yields (50-60%) of the corresponding dienes and enones (10-20%). No isomerized olefins were observed. Subsequent treatment of the dienes with tetraethylammonium fluoride gave the internal olefins, and thermal isomerization of 2,6-diphenyl-1-1,3,3,4,4,5,5,7,7-decafluoro-1,6-heptadiene to the internal isomeric olefins was observed at 250 °C.     

An unconstrained dual approach to solving Karmarkar-type linear programs using conventional barrier functions

This paper proposes an unconstrained dual approach and an efficient algorithm for solving Karmarkar-type linear programming problems. Conventional barrier functions are incorporated as a perturbation term in the derivation of the associated duality theory. An optimal solution of the original linear program can be obtained by solving a sequence of unconstrained concave programs, or be approximated by solving one such dual program with a sufficiently small perturbation parameter. A globally convergent curved-search algorithm with a quadratic rate of convergence is designed for this purpose. Based on our testing results, we find that the computational procedure is very efficient and can be a viable approach for solving linear programming problems.     

Design of A CWDM OADM for Fiber Optical Communication Network

A CWDM is proposed for fiber optic communication networks. The OADM is designed based on SOI structure. The scheme for CWDM optical signal protection is presented.     

Delay Time Measurement and Comparison of Protection Strategies with One-Link Failed Domestic Optical Fiber Networks in Taiwan

In this paper, we study the protection strategies of domestic optical fiber networks in Taiwan. Delay time experiment of two one-link failed cases are also reported and compared. We can get best protection strategy and bypass the optical transmission signal at shortest delay time.     

Analysis of a 32-Channal Benes Switching Network Including an SDM/WDM Router

An spatial division multiplexing/wavelength division multiplexing router is designed for applying in a fiber-optical wide area network. Our comparison shows various spans of the good SDM/WDM WAN using the SOA based router.     

Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics

The commonly used “stealth material” poly(ethylene glycol) (PEG) effectively promotes the pharmacokinetics of therapeutic cargos while reducing their immune response. However, recent studies have suggested that PEG could induce adverse reactions, including the emergence of anti‐PEG antibodies and tissue histologic changes. An alternative stealth material with no or less immunogenicity and organ toxicity is thus urgently needed. We designed a polypeptide with high zwitterion density (PepCB) as a stealth material for therapeutics. Neither tissue histological changes in liver, kidney, or spleen, nor abnormal behavior, sickness or death was induced by the synthesized polymer after high‐dosage administration for three months in rats. When conjugated to a therapeutic protein uricase, the uricase–PepCB bioconjugate showed significantly improved pharmacokinetics and immunological properties compared with uricase–PEG conjugates.     

The reaction of triplet flavin with indole. A study of the cascade of reactive intermediates using density functional theory and time resolved infrared spectroscopy

As a model for riboflavin, lumiflavin was investigated using density functional theory methods (B3LYP/6-31G* and B3LYP/6-31+G**) with regard to the proposed cascade of intermediates formed after excitation to the triplet state, followed by electron-transfer, proton-transfer, and radical[bond]radical coupling reactions. The excited triplet state of the flavin is predicted to be 42 kcal/mol higher in energy than the singlet ground state, and the pi radical anion lies 45.1 kcal/mol lower in energy than the ground-state flavin and a free electron in the gas phase. The former value compares to a solution-phase triplet energy of 49.8 kcal/mol of riboflavin. For the radical anion, the thermodynamically favored position to accept a proton on the flavin ring system is at N(5). A natural population analysis also provided spin density information for the radicals and insight into the origin of the relative stabilities of the six different calculated hydroflavin radicals. The resulting 5H-LF* radical can then undergo radical[bond]radical coupling reactions, with the most thermodynamically stable adduct being formed at C(4'). Vibrational spectra were also calculated for the transient species. Experimental time-resolved infrared spectroscopic data obtained using riboflavin tetraacetate are in excellent agreement with the calculated spectra for the triplet flavin, the radical anion, and the most stable hydroflavin radical.     

Novel and anti-inflammatory constituents of Garcinia subelliptica

Four novel phloroglucinol derivatives, garcinielliptones A (1), B (2), C (3), D (4), a novel triterpenoid, garcinielliptone E (5), and three known compounds were isolated from the seeds of Garcinia subelliptica. The structures, including relative configurations, were elucidated by means of spectroscopic data. Known compounds garsubellin A (6) and garcinielliptin oxide (7) showed potent inhibitory effects on the release of beta-glucuronidase, and beta-glucuronidase and histamine, respectively, from peritoneal mast cells stimulated with compound 48/80 in a concentration-dependent manner with IC(50) values of 15.6+/-2.5, and 18.2+/-3.6 and 20.0+/-2.7 microM, respectively. Compound 7 showed potent inhibitory effects on the release of beta-glucuronidase and lysozyme from neutrophils stimulated with formyl-Met-Leu-Phe(fMLP)/cytochalasin B (CB) in a concentration-dependent manner with IC(50) values of 15.7+/-3.0 and 23.9+/-3.2 microM, respectively. Compound 7 also showed potent inhibitory effect on superoxide formation from neutrophils stimulated with fMLP/CB also in a concentration-dependent manner with an IC(50) value of 17.9+/-1.5 microM.